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Sequence No.


Give one example of a gene responsible for multiple phenotype expressions. What are such genes called? State the cause that is responsible for such an effect.

Pleiotropy is the phenomenon in which a single gene exhibit multiple phenotypic expressions. The gene exhibiting pleiotropy are called pleiotropic genes. Pleiotropism occurs mainly because of mutation in a particular gene, e.g., phenyl ketonuria which is a disorder caused by mutation in the gene coding for the enzyme phenylalanine hydroxylase. In the absence of this enzyme, phenylalanine is not converted into tyrosine and accumulation of phenylalanine takes place. The affected individual shows hair and skin pigmentation and mental problems.

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