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Sequence No.
BIO-449
Briefly explain the contribution of the following:
(a) Friedrich Miescher
(b) Levene
(c) Chargaff
(d) Watson and Crick.
Answer:
(a) Friedrich Miescher (1869) first identified DNA as an acidic substance and named it nuclein.
(b) Leven (1910) found that DNA contains phosphoric acid as well as deoxyribose sugar. He also found that four types of nucleotides are present in DNA.
(c) Erwin Chargaff proposed that for a double stranded DNA, the ratio between purines (adenine + guanine) and pyrimidines (thymine + cytosine) are constant and equals to one,
A+GT+C=1�+��+�=1
(d) Watson and Crick (1953) proposed double helix model of DNA base on X - ray diffraction data proposed by Wilkins, and Franklin.
Reporting Question Sequence No.
BIO-449
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