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Sequence No.


Write the genotypes of the parents of a child suffering from thalassemia. State the cause of this disease.

The genotypes of the parents of a child suffering from thalassemia are as follows :
Mother : ThB ThB+
Father : ThB ThB+


Thalassemia is an autosomal - linked recessive disorder, which results in reduced rate of synthesis of one of the globin chains of haemoglobin. The disease is controlled by a single pair of allele, ThB and ThB+. ThB codes for normal ß-protein and ThB+ codes for an abnormal ß-protein. Only homozygous abnormal individuals for ThB+ (ThB+ ThB+)show the disease phenotype.

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